The Penetration of Moxifloxacin into the Pancreas of Male Rats in Experimental Acute Necrotizing Pancreatitis

• Published in: Chemotherapy (Basel) Vol. 49; no. 4; pp. 167 - 171
• Main Authors: Wacke, Rainer, Park, Sora, Mundkowski, Ralf G., Block, Norma, Kuhn-Thiel, Alexandra, Drewelow, Bernd
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.07.2003; S. Karger AG
• Subjects: Animals; Anti-Infective Agents - blood; Anti-Infective Agents - pharmacokinetics; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Aza Compounds; Bacterial Infections - etiology; Bacterial Infections - prevention & control; Biological and medical sciences; Fluoroquinolones; Male; Medical sciences; Pancreas - metabolism; Pancreatitis, Acute Necrotizing - complications; Pancreatitis, Acute Necrotizing - metabolism; Pharmacology; Pharmacology. Drug treatments; Quinolines; Rats; Rats, Wistar; Tissue Distribution; Acute necrotizing pancreatitis; Penetration in pancreatic tissue; Infectious complications; Moxifloxacin; Antibiotics; Intravenous administration; Rat; Male; Necrosis; Prevention; Tissue; Fluoroquinolone derivatives; Serum; Pancreas; Quinolone derivatives; Pancreatic disease; Opportunistic infection; Acute; Rodentia; Pancreatitis; Vertebrata; Chemotherapy; Mammalia; Penetration; Animal; Distribution; Digestive diseases; Antibacterial agent; Pharmacokinetics
• ISSN: 0009-3157; 1421-9794
• DOI: 10.1159/000071140

Infectious complications of acute necrotizing pancreatitis (ANP) determine the extent of multiorgan failure and account for 80% of deaths. Prophylactic use of antibiotics can reduce the incidence of these complications. However, the actual indication as well as choice of drug remains a controversial matter. We examined the penetration of moxifloxacin, a new broad-spectrum fluoroquinolone, in healthy and inflamed pancreatic tissue in rats after inducing ANP. The concentration of moxifloxacin in pancreatic tissue and serum was determined 10, 30, 60 and 240 min after the administration of moxifloxacin (5 mg/kg, i.v.). Mean serum concentrations 10 min after administration in rats with ANP were 1,886 ng/ml versus 1,805 ng/ml in healthy controls, and these values decreased to 350 versus 222 ng/ml, respectively, after 240 min. Corresponding concentrations in pancreatic tissue were in the mean 2–3 times higher.