Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga

Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the s...

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Bibliographic Details
Published inPlanta medica Vol. 75; no. 6; pp. 647 - 653
Main Authors Yuan, Wei-Hua, Yi, Yang-Hua, Tan, Ren-Xiang, Wang, Zeng-Lei, Sun, Guo-Quan, Xue, Mei, Zhang, Hong-Wei, Tang, Hai-Feng
Format Journal Article
LanguageEnglish
Published Germany 01.05.2009
Subjects
Animals
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
antifungal properties
arguside
chemical structure
Fungi - drug effects
glycosides
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
holostan triterpenes
Holothuria - chemistry
Holothuria axiloga
Holothuroidea
impatienside
pervicoside
spectral analysis
stereochemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
China
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Summary:Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 < or = MIC(80) < or = 4 microg/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X-ray diffraction analysis.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-0029-1185381