Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report

We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was tr...

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Bibliographic Details
Published inJournal of neuro-oncology Vol. 83; no. 2; pp. 199 - 204
Main Authors Kageji, Teruyoshi, Nagahiro, Shinji, Matsuzaki, Kazuhito, Kanematsu, Yasuhiko, Nakatani, Minoru, Okamoto, Yasuhiko, Watanabe, Tsutomu
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.06.2007
Subjects
Adolescent
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Basal ganglia
Brain Neoplasms - blood
Brain Neoplasms - drug therapy
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Carboplatin
Carboplatin - administration & dosage
Case reports
Chemotherapy
Choriocarcinoma
Choriocarcinoma - blood
Choriocarcinoma - drug therapy
Choriocarcinoma - radiotherapy
Choriocarcinoma - surgery
Chorionic Gonadotropin, beta Subunit, Human - blood
Combined Modality Therapy
Etoposide
Etoposide - administration & dosage
Humans
Magnetic resonance imaging
Male
Methotrexate
Methotrexate - administration & dosage
Neoadjuvant Therapy - methods
Peripheral blood
Peripheral Blood Stem Cell Transplantation
Radiation therapy
Stem cell transplantation
Treatment Outcome
Tumors
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Summary:We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.
Bibliography:ObjectType-Article-1
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ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-006-9311-1