Quantitative PET Scan Findings in Carbon Monoxide Poisoning: Deficits Seen in a Matched Pair

Quantitative positron emission tomography (PET) was utilized to establish the degree and localization of central nervous system dysfunction in 2 adult patients 3 years status postchronic carbon monoxide poisoning. The individual PET scans were compared against a composite scan made up of 32 normals...

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Published inArchives of clinical neuropsychology Vol. 15; no. 6; pp. 545 - 553
Main Authors Pinkston, James B, Wu, Joseph C, Gouvier, W.Drew, Varney, Nils R
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Ltd 01.08.2000
Elsevier
Subjects
Adult and adolescent clinical studies
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Gas, fumes
Medical sciences
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Toxicology
Radionuclide study
Human
Temporal lobe
Memory disorder
Frontal lobe
Cognitive disorder
Toxicity
Daily living
Central nervous system
Activity
Prefrontal cortex
Language disorder
Carbon monoxide
Brain (vertebrata)
Emission tomography
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Summary:Quantitative positron emission tomography (PET) was utilized to establish the degree and localization of central nervous system dysfunction in 2 adult patients 3 years status postchronic carbon monoxide poisoning. The individual PET scans were compared against a composite scan made up of 32 normals using a z transformation statistical parametric map. Neuropsychological findings indicated marked anterior frontal lobe syndrome in the context of far-above-average intelligence, memory, and language. They also showed manifest frontal symptoms in activities of daily living that resulted in vocational disability in each case. PET analysis revealed substantially decreased metabolism in the orbitofrontal and dorsolateral prefrontal cortex as well as in areas of the temporal lobe for each individual. Individual scans were very similar and consistent with patient's presenting symptoms, and changed life circumstances. This report represents the first quantitative functional neuroimaging study relevant to carbon monoxide poisoning. Published by Elsevier Science Ltd
ISSN:0887-6177
1873-5843
DOI:10.1016/S0887-6177(99)00051-7