Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities

• Published in: Bioorganic & medicinal chemistry letters Vol. 19; no. 5; pp. 1534 - 1538
• Main Authors: Sondhi, Sham M., Rani, Reshma, Roy, Partha, Agrawal, S.K., Saxena, A.K.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.03.2009; Elsevier
• Subjects: Animals; Anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - radiation effects; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Anticancer; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - radiation effects; Antineoplastic Agents - therapeutic use; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cyclicimide; Drug Evaluation, Preclinical - methods; Edema - drug therapy; Female; Humans; Imides - chemical synthesis; Imides - radiation effects; Imides - therapeutic use; Life Sciences & Biomedicine; Male; Microwave; Microwaves; Pharmacology & Pharmacy; Physical Sciences; Rats; Science & Technology; Microwave; Cyclicimide; Anticancer; Anti-inflammatory; GRANULATIMIDE; ASSAY; ANALOGS; INHIBITORS; ISOGRANULATIMIDE
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2008.07.048

A number of N-substituted cyclic imides have been synthesized and screened for anticancer been synthesized and screened for anticancer 9c exhibited good anticancer activity against colon (COLO-205) cancer and 9b exhibited good anti-inflammatory activity. A number of N-substituted cyclic imides 3a– e, 5a– e, 7a– d, and 9a– e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.