Renal Effects of an Angiotensin II Antagonist in Stroke-Prone Spontaneously Hypertensive Rat

• Published in: Nephron Vol. 76; no. 4; pp. 466 - 471
• Main Authors: Yo, Yoshikage, Moriguchi, Atsushi, Higaki, Jitsuo, Nagano, Masahiro, Nakano, Nobuaki, Kamide, Kei, Yu, Hisahiro, Mikami, Hiroshi, Ogihara, Toshio
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 1997
• Subjects: Angiotensin I - antagonists & inhibitors; Angiotensin I - metabolism; Angiotensin II - antagonists & inhibitors; Angiotensin II - metabolism; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds - pharmacology; Blood Pressure - drug effects; Body Weight - drug effects; Cerebrovascular Disorders - genetics; Cerebrovascular Disorders - physiopathology; Dose-Response Relationship, Drug; Heart Rate - drug effects; Hypertension - genetics; Hypertension - physiopathology; Imidazoles - pharmacology; Kidney - drug effects; Kidney Function Tests; Kidney Glomerulus - drug effects; Kidney Glomerulus - ultrastructure; Losartan; Organ Size - drug effects; Original Paper; Proteinuria - drug therapy; Proteinuria - urine; Rats; Rats, Inbred SHR; Receptors, Angiotensin - metabolism; Tetrazoles - pharmacology; Tissue Embedding; HR 720; Hypertension; Angiotensin II type 1 receptor antagonist; Glomerular sclerosis; Urinary protein
• ISSN: 1660-8151; 2235-3186
• DOI: 10.1159/000190230

We evaluated the renal effects of the new angiotensin II type 1 (ATI) receptor antagonist, HR 720, in the stroke-prone spontaneously hypertensive rat. Rats were treated with either vehicle, HR 720, MK-954 (a selective ATI receptor antagonist) or enalapril for 6 weeks. Blood pressure was decreased to a similar extent by HR 720, MK-954 and enalapril (203 ± 4, 202 ± 5 and 190 ± 4 vs. 247 ± 4 mm Hg for control). Urinary protein secretion was also decreased (5.2 ± 0.3, 5.3 ± 0.2 and 5.5 ± 0.6 vs. 25.2 ± 4.6 mg/l00g/24h). The glomerular hypertensive change was improved in each drug-treated group (2.0 ± 0.2, 3.3 ± 0.3 and 1.6 ± 0.1 vs. 17.6 ± 1.5%; p < 0.0001). These results show that, in addition to its antihypertensive effect, HR 720 has a beneficial effect on renal function.