Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue “optical window”. The spectral polarization imaging of Cybesin-stained prostat...

Full description

Saved in:
Bibliographic Details
Published inTechnology in cancer research & treatment Vol. 4; no. 4; pp. 429 - 436
Main Authors Pu, Y., Wang, W. B., Tang, G. C., Zeng, F., Achilefu, S., Vitenson, J. H., Sawczuk, I., Peters, S., Lombardo, J. M., Alfano, R. R.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2005
Subjects
Bombesin - chemistry
Contrast Media - pharmacology
Humans
Male
Models, Chemical
Peptides - chemistry
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Spectrometry, Fluorescence
Spectrophotometry
Spectroscopy, Near-Infrared - instrumentation
Spectroscopy, Near-Infrared - methods
and Fluorescence
Absorption
Contrast agent
Near-infrared
Peptide analogue conjugate
Spectral polarization imaging
Prostate cancer
Receptor-targeted
Online AccessGet full text

Cover

More Information
Summary:The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue “optical window”. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1533-0346
1533-0338
DOI:10.1177/153303460500400410