Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice

Abstract Mast cells (MCs) play a critical role in oral allergen-induced anaphylaxis. However, the contribution of basophils to the anaphylaxis remains unclear. The inhibitory immunoreceptor Allergin-1 is highly expressed on MCs and basophils and inhibits FcεRI-mediated signaling in MCs. Here, we sho...

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Published inInternational immunology Vol. 32; no. 3; pp. 213 - 219
Main Authors Lin, Yu-Hsien, Tahara-Hanaoka, Satoko, Nagai, Kei, Yoshikawa, Soichiro, Kubo, Masato, Shibayama, Shiro, Karasuyama, Hajime, Shibuya, Akira
Format Journal Article
LanguageEnglish
Published UK Oxford University Press 07.03.2020
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Summary:Abstract Mast cells (MCs) play a critical role in oral allergen-induced anaphylaxis. However, the contribution of basophils to the anaphylaxis remains unclear. The inhibitory immunoreceptor Allergin-1 is highly expressed on MCs and basophils and inhibits FcεRI-mediated signaling in MCs. Here, we show that Allergin-1-deficient (Milr1−/−) mice developed more severe hypothermia, a higher mortality rate and a greater incidence of diarrhea than did wild-type (WT) mice in an oral ovalbumin (OVA)-induced food allergy model. MC-deficient Mas–TRECK mice, which had been reconstituted with either WT or Milr1−/− bone marrow-derived cultured MCs, did not develop hypothermia in this food allergy model. On the other hand, depletion of basophils by injection of anti-CD200R3 antibody rescued Milr1−/− mice from lethal hypothermia but not from diarrhea. In vitro analyses demonstrated that Allergin-1 inhibits IgE-dependent activation of both human and mouse basophils. Thus, Allergin-1 on basophils selectively suppresses oral allergen-induced anaphylaxis. Basophil Allergin-1 inhibits oral allergen-induced anaphylaxis
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ISSN:1460-2377
1460-2377
DOI:10.1093/intimm/dxz075