Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy

Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 48; no. 12; pp. 1754 - 1756
Main Authors Díaz, Agustín, Saxena, Vipin, González, Julissa, David, Amanda, Casañas, Barbara, Carpenter, Carrie, Batteas, James D., Colón, Jorge L., Clearfield, Abraham, Delwar Hussain, M.
Format Journal Article
LanguageEnglish
Published England 01.01.2012
Subjects
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - pharmacology
breast neoplasms
Breast Neoplasms - drug therapy
cancer therapy
Cell Line, Tumor
Cell Survival - drug effects
chemical communication
chemical reactions
cytotoxicity
doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - pharmacology
Drug Carriers - chemistry
Female
human cell lines
Humans
Nanostructures - chemistry
Nanostructures - ultrastructure
neoplasm cells
phosphates
zirconium
Zirconium - chemistry
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Summary:Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c2cc16218k