Use of autologous bone marrow mesenchymal stem cells for healing of free full-thickness skin graft in a zone with pronounced hypoperfusion of soft tissues caused by arteriovenous shunting

• Published in: Bulletin of experimental biology and medicine Vol. 142; no. 1; pp. 123 - 128
• Main Authors: Bystrov, A V, Polyaev, Yu A, Pogodina, M A, Rasulov, M F, Krasheninnikov, M E, Onishchenko, N A
• Format: Journal Article
• Language: English; Russian
• Published: United States Springer Nature B.V 01.07.2006
• Subjects: Adult; Arteriovenous Fistula - congenital; Arteriovenous Fistula - pathology; Arteriovenous Fistula - surgery; Arteriovenous Fistula - therapy; Autografts; Blood Vessels - diagnostic imaging; Bone healing; Bone marrow; Bone marrow transplantation; Bone Marrow Transplantation - methods; Cardiovascular system; Carotid artery; Face - blood supply; Face - pathology; Female; Humans; Ligation - methods; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Microscopy, Fluorescence; Occlusion; Skin Transplantation - methods; Soft tissues; Stem cells; Treatment Outcome; Tumors; Ultrasonography; Wound Healing - physiology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-006-0309-7

A combined graft consisting of a free full-thickness skin flap and cultured autologous fibroblast-like bone marrow mesenchymal stem cells was effectively implanted and healed on the facial soft tissue defect after removal of a pathological vascular conglomeration in a female patient with congenital arteriovenous macrofistulous dysplasia. In order to reduce bloodflow intensity and arteriovenous shunting, repeated endovascular occlusion and transcutaneous ligature of regional vessels from the carotid artery basin feeding the pathological zone was carried out followed by resection of this tumor-like vascular formation.