Potential of sodium dodecyl sulfate micellar solutions as eluents in magnetic dispersive micro-solid phase extraction with polydopamine-coated magnetite nanoparticles. Application to antidepressant drugs

• Published in: Journal of Chromatography A Vol. 1680; p. 463430
• Main Authors: Pérez-Baeza, Mireia, Escuder-Gilabert, Laura, Martín-Biosca, Yolanda, Sagrado, Salvador, Medina-Hernández, María José
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 13.09.2022
• Subjects: Antidepressant drugs; Dispersive micro-solid phase extraction; Polydopamine-coated magnetite nanoparticles; Sodium dodecyl sulfate micellar eluents; Sodium dodecyl sulfate micellar eluents; Polydopamine-coated magnetite nanoparticles; Dispersive micro-solid phase extraction; Antidepressant drugs
• ISSN: 0021-9673
• DOI: 10.1016/j.chroma.2022.463430

•Dispersive micro-solid phase extraction (D-μSPE) for antidepressant drugs (AD)•Fe3O4@Polydopamine nanoparticles (Fe3O4@PDA NPs) shows strong affinity towards AD•Sodium dodecyl sulfate (SDS) micellar eluents in D-μSPE are used for the first time•SDS micellar eluents is clearly advantageous over classic hydro-organic eluents•Excellent stability and reusability of Fe3O4@PDA NPs In this paper, the potential of micellar solutions of the anionic surfactant sodium dodecyl sulfate (SDS) as eluents in dispersive micro-solid phase extraction (D-μSPE) using polydopamine-coated magnetite nanoparticles (Fe3O4@PDA NPs) for the extraction and preconcentration of seven basic drugs (bupropion, citalopram, fluoxetine, mianserin, nomifensine, trimipramine, and viloxazine) is explored for the first time (to the best to our knowledge) and compared with conventional hydro-organic eluents. The impact of the sample solution pH, Fe3O4@PDA NPs and PDA coating amounts and extraction time on the extraction efficiency (EE), as well as the composition of the eluent on the overall efficiency (OE) are studied. Under the selected experimental conditions (50 mg of Fe3O4@PDA NPs, 100 μL of 1 M NH3, 5 min of extraction time and 0.15 M SDS at pH 2.6 as eluent), EE and OE values were higher than 90% for all compounds and for the most hydrophobic compounds (trimipramine, fluoxetine and mianserin), respectively. The results shown in this paper demonstrate the suitability of Fe3O4@PDA NPs as a sorbent for the extraction of antidepressants as well as the advantages of using SDS micellar solutions over classic hydro-organic eluents containing methanol, acetonitrile or tetrahydrofuran. Finally, the stability and reusability of the Fe3O4@PDA NPs is proven.