Seroprevalence of herpes simplex virus types 1 and type 2 in the Frankfurt am Main area, Germany

• Published in: Medical microbiology and immunology Vol. 190; no. 4; pp. 153 - 160
• Main Authors: RABENAU, H. F, BUXBAUM, S, PREISER, W, WEBER, B, DOERR, H. W
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.03.2002; Springer Nature B.V
• Subjects: Adolescent; Adult; Age Factors; Animal viral diseases; Antibodies, Viral - blood; Biological and medical sciences; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; Germany - epidemiology; Herpes Genitalis - epidemiology; Herpes Simplex - epidemiology; Herpes simplex virus 1; Herpes simplex virus 2; Herpes viruses; Herpesvirus 1, Human - immunology; Herpesvirus 2, Human - immunology; Humans; Immunosuppression - adverse effects; Infectious diseases; Male; Medical sciences; Microbiology; Retrospective Studies; Seroepidemiologic Studies; Sex Factors; Viral diseases; Virology; Europe; Germany; Frankfurt Germany; Alphaherpesvirinae; IgG; Male; Epidemiology; Specificity; Herpesvirus hominis 1; Herpesvirus hominis 2; Female; Herpesvirus hominis; Human; Immunopathology; Antibody; Herpesviridae; Retroviridae; Herpes; AIDS; Immune deficiency; Lentivirus; HIV-2 virus; Infection; Virus; Latent; Sexually transmitted disease; Viral disease; Persistent infection; Sexuality; Human immunodeficiency virus; Saliva
• ISSN: 0300-8584; 1432-1831
• DOI: 10.1007/s00430-001-0102-1

Herpes simplex virus (HSV) types 1 and 2 are widespread human infectious agents that are responsible for persistent and latent infections. HSV type 2 (HSV-2) infection is usually transmitted sexually, while HSV type I (HSV-1) is commonly acquired by saliva contact during childhood. In a retrospective study, sera from more than 4,800 patients were analyzed for HSV type-specific IgG antibodies. In people older than 15 years, the seroprevalence of HSV-1 showed no statistically significant discrepancy between the control group (76.3% in females and 75.2% in males), HIV-infected patients (82.8% in females and 84.3% in males), and organ transplant (OTX) recipients (90.3% in females and 86.3% in males) (P>0.05). Age-related analysis of the control group showed that there is an age-dependent increase of HSV-1 seroprevalence in both sexes, reaching its peak in those aged 40 years and older (women 85.4%, men 82.8%). The only age group in which there is a significantly higher seropositivity rate in women than in men is in those aged between 15 and 39 years, with 70.8% versus 63.7% (P<0.05). As with HSV-1, there is an age-related increase of the HSV-2 seroprevalence; however, this increase starts later in life, with the onset of sexual activity. The HSV-2 prevalence across all age groups was highest in female prostitutes (78.0%) and among HIV-infected patients (women 64.1%, men 54.3%); this contrasts with the control group (overall women 17%, men 12.5%; those above 15 years of age, women 18%, men 13.8%) and the OTX patients (women 22.6%, men 9.8%). In the control group the rate of positivity increases with age and peaks in the group older than 40 years (24.2% in women and 16.2% in men). In females the seroprevalence is always elevated compared with males. The data presented show that female sex and older age are independent predictors of HSV-2 seropositivity, while immunosuppression is not. Our additional data show no evidence of a statistically significant humoral HSV-1/HSV-2 cross-immunity. People with HSV-1 serum antibodies have no lower risk of HSV-2 seropositivity than those lacking antibodies to HSV-1. The same is true when investigating HSV-1 seroprevalence rates in HSV-2-seropositive or -negative individuals, retrospectively.