Human Immunodeficiency Virus Type 1 Seroconversion in Women with Genital Ulcers

• Published in: The Journal of infectious diseases Vol. 170; no. 2; pp. 313 - 317
• Main Authors: Plourde, Pierre J., Pepin, Jacques, Agoki, Elizabeth, Ronald, Allan R., Ombette, John, Tyndall, Mark, Cheang, Mary, Ndinya-Achola, Jackoniah O., D'Costa, Lourdes J., Plummer, Francis A.
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 01.08.1994; University of Chicago Press
• Subjects: Adolescent; Adult; AIDS; AIDS/HIV; Cervix Uteri - abnormalities; Confidence Intervals; Female; Follow-Up Studies; Genital Diseases, Female - complications; Genitalia; HIV; HIV 1; HIV Seropositivity - epidemiology; human immunodeficiency virus 1; Humans; Incidence; Infections; Kenya - epidemiology; Major Articles; Middle Aged; Pelvic inflammatory disease; Pelvic Inflammatory Disease - complications; Prospective Studies; Prostitution; Risk Factors; Sex Work; Sexual Behavior; Sexually transmitted diseases; Ulcer - complications; Ulcers; Women
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/170.2.313

Genital ulcers are implicated as a risk factor enhancing susceptibility to human immunodeficiencyvirus type 1(HIV-1)infection. Aprospectivestudytodeterminetheincidenceofand risk factors associated with acquisition of HIV-I in women with genital ulcers was done. HIV-1-seronegative women with genital ulcers attending a clinic for sexually transmitted diseases in Nairobi werefollowedto HIV-1 seroconversionovera6-month period. Of 81women, 10seroconverted to HIV-1. The crude 6-month incidence of HIV-1 infection was 12%. Risk factors associated with seroconversion included cervical ectopy (rate ratio [RR], 4.9; 95% confidence interval [CI], 1.5-15.6) and pelvic inflammatory disease (RR, 6.3; 95% CI, 1.9-20.4). Thus, cervical ectopy and pelvic inflammatory disease may increase susceptibility to HIV-1 in women with genital ulcers.