Alkyne-X modification of polypeptoids

[Display omitted] •Alkyne-X (“click”) chemistry: cyclo, radical, and nucleophilic addition reactions.•Modular platform of functionalizable polypeptoids.•Synthesis of polypeptoid ionic liquids and graft copolymers. Poly(N-propargyl glycine) (PNPG) can be readily prepared by ring-opening polymerizatio...

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Bibliographic Details
Published inEuropean polymer journal Vol. 62; pp. 394 - 399
Main Authors Secker, Christian, Robinson, Joshua W., Schlaad, Helmut
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.01.2015
Subjects
Addition polymerization
Alkynes
Click chemistry
Ethylene oxide
Glycine
Graft copolymers
Ionic liquids
NCA
Platforms
Polypeptoid
Post-polymerization modification
Radicals
Click chemistry
Polypeptoid
Post-polymerization modification
NCA
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Summary:[Display omitted] •Alkyne-X (“click”) chemistry: cyclo, radical, and nucleophilic addition reactions.•Modular platform of functionalizable polypeptoids.•Synthesis of polypeptoid ionic liquids and graft copolymers. Poly(N-propargyl glycine) (PNPG) can be readily prepared by ring-opening polymerization of N-propargyl glycine N-carboxyanhydride (NCA) and modified using various addition reactions such as copper catalyzed [3+2] cycloaddition of azide, radical (photo-)addition of thiol, nucleophilic addition of ethylene oxide, and thermal induced cross-linking. It is demonstrated that PNPG can serve as a modular platform to produce a bibliography of novel functional polypeptoid or pseudopeptide materials, including polypeptoid ionic liquids and graft copolymers.
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content type line 23
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2014.08.028