IL-7: A key regulator of B lymphopoiesis

Interleukin-7 plays important roles in the B cell developmental pathway including events leading to commitment, survival, proliferation, and maturation. Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro. We have shown that di...

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Bibliographic Details
Published inSeminars in Immunology Vol. 18; no. 1; pp. 20 - 30
Main Authors Milne, Craig D., Paige, Christopher J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2006
Subjects
Animals
B cells
B-Lymphocytes - cytology
B-Lymphocytes - physiology
CD45
Cell differentiation
Cell Differentiation - physiology
Humans
IL-7
Interleukin-7 - physiology
Lymphopoiesis - physiology
Signal Transduction - immunology
B cells
Cell differentiation
CD45
IL-7
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Summary:Interleukin-7 plays important roles in the B cell developmental pathway including events leading to commitment, survival, proliferation, and maturation. Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro. We have shown that differentiation of IL-7-responsive cells in these cultures is influenced by CD45, pre-B cell receptor, and other downstream signaling molecules. A common, but often overlooked aspect of IL-7 containing cultures is the routine maturation of cells to the sIgM + stage. The production of B cells in IL-7 containing cultures is balanced by cell death, since such cells fail to survive for long without additional stimulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1044-5323
1096-3618
1365-2567
DOI:10.1016/j.smim.2005.10.003