Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis
Recent studies have shown that mieroRNA-21 (miR-21) con- tributes to tumor resistance to chemotherapy. Interestingly, we have found that berberine could inhibit miR-21 expres- sion in several cancer cell lines. In this study, we investigated whether berberine could modulate the sensitivity of ovaria...
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Published in | Acta biochimica et biophysica Sinica Vol. 45; no. 9; pp. 756 - 762 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
China
01.09.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Recent studies have shown that mieroRNA-21 (miR-21) con- tributes to tumor resistance to chemotherapy. Interestingly, we have found that berberine could inhibit miR-21 expres- sion in several cancer cell lines. In this study, we investigated whether berberine could modulate the sensitivity of ovarian cancer cells to cisplatin and explored the mechanism. The cisplatin-resistant SKOV3 cells that were incubated with berberine combined with cisplatin had a significantly lower survival than the cisplatin alone group and enhanced cis- platin-induced apoptosis. Berberine could inhibit miR-21 expression and function in ovarian cancer, as shown by an enhancement of its target PDCD4, an important tumor sup- pressor in ovarian cancer. The results suggested that berber- ine could modulate the sensitivity of cisplatin via regulating miR-21/PDCD4 axis in the ovarian cancer cells. |
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Bibliography: | 31-1940/Q Recent studies have shown that mieroRNA-21 (miR-21) con- tributes to tumor resistance to chemotherapy. Interestingly, we have found that berberine could inhibit miR-21 expres- sion in several cancer cell lines. In this study, we investigated whether berberine could modulate the sensitivity of ovarian cancer cells to cisplatin and explored the mechanism. The cisplatin-resistant SKOV3 cells that were incubated with berberine combined with cisplatin had a significantly lower survival than the cisplatin alone group and enhanced cis- platin-induced apoptosis. Berberine could inhibit miR-21 expression and function in ovarian cancer, as shown by an enhancement of its target PDCD4, an important tumor sup- pressor in ovarian cancer. The results suggested that berber- ine could modulate the sensitivity of cisplatin via regulating miR-21/PDCD4 axis in the ovarian cancer cells. ovarian cancer; berberine; miR-21 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1672-9145 1745-7270 |
DOI: | 10.1093/abbs/gmt075 |