Global epidemiologic patterns of oropharyngeal cancer incidence trends

• Published in: JNCI : Journal of the National Cancer Institute Vol. 115; no. 12; pp. 1544 - 1554
• Main Authors: Zumsteg, Zachary S, Luu, Michael, Rosenberg, Philip S, Elrod, Julia K, Bray, Freddie, Vaccarella, Salvatore, Gay, Christopher, Lu, Diana J, Chen, Michelle M, Chaturvedi, Anil K, Goodman, Marc T
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 06.12.2023
• Subjects: Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell - etiology; Female; Head and Neck Neoplasms; Humans; Incidence; Lung Neoplasms - epidemiology; Male; Middle Aged; Mouth Neoplasms - epidemiology; Oropharyngeal Neoplasms - pathology; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djad169

The emergence of human papillomavirus (HPV)-positive oropharyngeal cancer and evolving tobacco use patterns have changed the landscape of head and neck cancer epidemiology internationally. We investigated updated trends in oropharyngeal cancer incidence worldwide. We analyzed cancer incidence data between 1993 and 2012 from 42 countries using the Cancer Incidence in Five Continents database volumes V through XI. Trends in oropharyngeal cancer incidence were compared with oral cavity cancers and lung squamous cell carcinomas using log-linear regression and age period-cohort modeling. In total, 156 567 oropharyngeal cancer, 146 693 oral cavity cancer, and 621 947 lung squamous cell carcinoma patients were included. Oropharyngeal cancer incidence increased (P < .05) in 19 and 23 countries in men and women, respectively. In countries with increasing male oropharyngeal cancer incidence, all but 1 had statistically significant decreases in lung squamous cell carcinoma incidence, and all but 2 had decreasing or nonsignificant net drifts for oral cavity cancer. Increased oropharyngeal cancer incidence was observed both in middle-aged (40-59 years) and older (≥60 years) male cohorts, with strong nonlinear birth cohort effects. In 20 countries where oropharyngeal cancer incidence increased for women and age period-cohort analysis was possible, 13 had negative or nonsignificant lung squamous cell carcinoma net drifts, including 4 countries with higher oropharyngeal cancer net drifts vs both lung squamous cell carcinoma and oral cavity cancer (P < .05 for all comparisons). Increasing oropharyngeal cancer incidence is seen among an expanding array of countries worldwide. In men, increased oropharyngeal cancer is extending to older age groups, likely driven by human papillomavirus-related birth cohort effects. In women, more diverse patterns were observed, suggesting a complex interplay of risks factors varying by country, including several countries where female oropharyngeal cancer increases may be driven by HPV.