Long-term exposure to PM2.5 and fasting plasma glucose in non-diabetic adolescents in Yogyakarta, Indonesia

• Published in: Environmental pollution (1987) Vol. 257; p. 113423
• Main Authors: Yu, Wenhua, Sulistyoningrum, Dian Caturini, Gasevic, Danijela, Xu, Rongbin, Julia, Madarina, Murni, Indah Kartika, Chen, Zhuying, Lu, Peng, Guo, Yuming, Li, Shanshan
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.02.2020
• Subjects: Diabetes; Fasting plasma glucose; Indonesia; Long-term; PM2.5; Long-term; Diabetes; Fasting plasma glucose; PM2.5; Indonesia
• ISSN: 0269-7491; 1873-6424
• DOI: 10.1016/j.envpol.2019.113423

Indonesia is facing serious air pollution. However, very few studies have been conducted to examine the health risks of air pollution in Indonesia, particularly for adolescents. To assess the association between long-term exposure to ambient particles with a diameter of <2.5 μm (PM2.5) and fasting plasma glucose (FPG) in adolescents. A cross-sectional study was conducted in 482 adolescents aged 14–18 years in Yogyakarta, Indonesia in 2016. We finally included 469 (97.30%) participants who had no missing data for data analysis. We collected individual data on socio-demographics, behavioral habits, and health information through standardized questionnaires. Satellite-based PM2.5 concentrations from 2013 to 2016 were assigned based on participants’ residential addresses. The association between PM2.5 and FPG was examined using a generalized linear regression model while FPG was modeled as a continuous variable. An ordered logistic regression model was used to assess the relationship between PM2.5 and FPG categories. Every 1 μg/m³ increase in PM2.5 was associated with a 0.34 mg/dL [95 confidence interval (95% CI): 0.08 mg/dL, 0.59 mg/dL] increase in FPG levels. Comparing with the low FPG level (under 86 mg/dL), every 1 μg/m³ increase in PM2.5 was associated with a 10.20% (95% CI: 1.60%, 19.80%) increase in the odds of impaired fasting glucose (IFG) (100–125 mg/dL). Stratified analyses indicated greater effects on participants with hypertension [odds ratio (OR) = 1.30, 95% CI: 1.09, 1.57] and those had higher physical activities (OR = 1.36, 95% CI: 1.09, 1.57). Adolescents’ sex, obesity status and different cutoff points of FPG did not modify the association between the exposure to PM2.5 and FPG levels. Long-term exposure to PM2.5 was associated with increased FPG levels in Indonesian non-diabetic adolescents. [Display omitted] •First assessment of PM2.5 related fasting plasma glucose in Indonesian adolescents.•Increase in PM2.5 was associated with elevated fasting plasma glucose.•Greater associations in teenagers with hypertension or higher physical activities. Long-term exposure to PM2.5 was associated with higher FPG levels in adolescents without diabetes in Indonesia, which provides scientific evidence for elevated fasting plasma glucose risk related to PM2.5 exposure.