Preferential impairment of parasympathetic autonomic function in type 2 diabetes

• Published in: Autonomic neuroscience Vol. 243; p. 103026
• Main Authors: Rasmussen, Thorsten K., Finnerup, Nanna B., Singer, Wolfgang, Jensen, Troels S., Hansen, John, Terkelsen, Astrid J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2022
• Subjects: Autonomic nervous system; Autonomic neuropathy; Autonomic vascular control; Cardiac autonomic regulation; Type 2 diabetes; Type 2 diabetes; Autonomic vascular control; Autonomic neuropathy; Autonomic nervous system; Cardiac autonomic regulation
• ISSN: 1566-0702; 1872-7484
• DOI: 10.1016/j.autneu.2022.103026

Cardiovascular autonomic neuropathy is a known complication in type 2 diabetes (T2D). However, the extent of sympathetic dysfunction and its relation to blood pressure (BP) dysregulation is insufficiently studied. We therefore assessed the cardiovascular sympathetic function using a standardized autonomic test-battery. Forty T2D patients (mean age and duration of diabetes ±SD, 65.5 ± 7.3 and 9.5 ± 4.2 years) and 40 age- and gender-matched controls were examined through autonomic testing, assessing cardiovascular responses to deep breathing, Valsalva maneuver and tilt-table testing. Additionally, 24-hour oscillometric BP and self-reported autonomic symptoms on COMPASS-31 questionnaire was recorded. Patients with T2D had reduced parasympathetic activity with reduced deep breathing inspiratory:expiratory-ratio (median [IQR] T2D 1.11 [1.08–1.18] vs. controls 1.18 [1.11–1.25] (p = 0.01)), and reduced heart rate variability (p < 0.05). We found no differences in cardiovascular sympathetic function measured through BP responses during the Valsalva maneuver (p > 0.05). 24-hour-BP detected reduced night-time systolic BP drop in T2D (9.8 % ± 8.8 vs. controls 15.8 % ± 7.7 (p < 0.01)) with more patients having reverse dipping. Patients with T2D reported more symptoms of orthostatic intolerance on the COMPASS-31 (p = 0.04). Patients with T2D showed reduced parasympathetic activity but preserved short-term cardiovascular sympathetic function, compared to controls, indicating autonomic dysfunction with predominantly parasympathetic impairment. Despite this, T2D patients reported more symptoms of orthostatic intolerance in COMPASS-31 and had reduced nocturnal BP dipping, indicating that these are not a consequence of cardiovascular sympathetic dysfunction. •Sympathetic cardiovascular reflexes are preserved in type 2 diabetes.•24-hour BP and sympathetic reflexes are not interchangeable markers.•Cardiac parasympathetic function is reduced in type 2 diabetes.