The Optimal Management of Neisseria gonorrhoeae Infections

• Published in: Microorganisms (Basel) Vol. 10; no. 12; p. 2388
• Main Authors: Ursu, Ramona Gabriela, Luchian, Ionut, Damian, Costin, Porumb-Andrese, Elena, Cobzaru, Roxana Gabriela, Nichitean, Giorgio, Ripa, Carmen, Costin, Diana, Sandu, Darius, Andrioaie, Ioana-Maria, Iancu, Luminita Smaranda
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: AMR detection assay; Annual reports; Antibiotics; Antibodies; Antigens; Antimicrobial agents; Antimicrobial resistance; Disease transmission; Drug development; Drug resistance; Gene sequencing; Genomes; gonococcal infections; Gonorrhea; Infections; Medical research; Neisseria gonorrhoeae; new drugs; NG vaccine candidate; Pathogens; Pregnancy complications; Proteins; R&D; Research & development; Researchers; Review; Ribonucleotide reductase; Sexually transmitted diseases; STD; Sterility; Teenagers; Vaccines; Vagina; Whole genome sequencing; Australia; United States > US; AMR detection assay; gonococcal infections; NG vaccine candidate; new drugs
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms10122388

is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the burden. In addition, anti- vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide.