Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma
Resident memory CD8 T (T ) cells in the lung parenchyma (LP) and airways provide heterologous protection against influenza virus challenge. However, scant knowledge exists regarding factors necessary to establish and maintain lung CD8 T . Here we demonstrate that, in contrast to mechanisms described...
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Published in | Mucosal immunology Vol. 11; no. 4; pp. 1071 - 1078 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.07.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Resident memory CD8 T (T
) cells in the lung parenchyma (LP) and airways provide heterologous protection against influenza virus challenge. However, scant knowledge exists regarding factors necessary to establish and maintain lung CD8 T
. Here we demonstrate that, in contrast to mechanisms described for other tissues, airway, and LP CD8 T
establishment requires cognate antigen recognition in the lung. Systemic effector CD8 T cells could be transiently pulled into the lung in response to localized inflammation, however these effector cells failed to establish tissue residency unless antigen was present in the pulmonary environment. The interaction of effector CD8 T cells with cognate antigen in the lung resulted in increased and prolonged expression of the tissue-retention markers CD69 and CD103, and increased expression of the adhesion molecule VLA-1. The inability of localized inflammation alone to establish lung T
resulted in decreased viral clearance and increased mortality following heterosubtypic influenza challenge, despite equal numbers of circulating memory CD8 T cells. These findings demonstrate that pulmonary antigen encounter is required for the establishment of lung CD8 T
and may inform future vaccine strategies to generate robust cellular immunity against respiratory pathogens. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1933-0219 1935-3456 1935-3456 |
DOI: | 10.1038/s41385-018-0003-x |