Semaphorin signaling: progress made and promises ahead

Semaphorins were initially characterized according to their role in repulsive axon guidance but are now recognized as crucial regulators of morphogenesis and homeostasis over a wide range of organ systems. The pleiotropic nature of semaphorin signaling and its implication in human disease has trigge...

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Bibliographic Details
Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 33; no. 4; pp. 161 - 170
Main Authors Zhou, Yeping, Gunput, Rou-Afza F., Pasterkamp, R. Jeroen
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2008
Subjects
Animals
Axons - metabolism
Cell Movement
Homeostasis
Humans
Ligands
Models, Biological
Neoplasms - metabolism
Phosphorylation
Protein Structure, Tertiary
Regeneration
Semaphorins - metabolism
Semaphorins - physiology
Signal Transduction
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Summary:Semaphorins were initially characterized according to their role in repulsive axon guidance but are now recognized as crucial regulators of morphogenesis and homeostasis over a wide range of organ systems. The pleiotropic nature of semaphorin signaling and its implication in human disease has triggered an enormous interest in the receptor and intracellular signaling mechanisms that direct the cell-type-specific and diverse biological effects of semaphorins. Recent breakthroughs in our understanding of semaphorin signaling link integrin and semaphorin signaling pathways, identify novel ligand–receptor interactions and provide insight into the cellular and molecular bases of bifunctional and reverse signaling events. These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases.
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ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2008.01.006