Polymer―metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(II), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(L-aspartic acid) (PEG-PLAn; molecular weight of PEG segment =...

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Published inJournal of materials chemistry Vol. 19; no. 26; pp. 4627 - 4631
Main Authors KIM, Jongsu, YOON, Hee-Jae, KIM, Suhyun, WANG, Kangkyun, ISHII, Takehiko, KIM, Yong-Rok, JANG, Woo-Dong
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 01.01.2009
Subjects
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Exact sciences and technology
Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation
Photoluminescence
Physics
Drugs
Phosphates
Dendrimer
Drug delivery systems
Aromatic polymer
Photoluminescence
Drug carrier
Laser irradiation
Lead sulfide
Polyethylene glycols
Molecular weight
Ethylene oxide polymer
Laser radiation
Micelles
Illumination
Polymers
Coordination bond
Radiation effects
Photodynamic therapy
Light scattering
Metal complex
Polymerization
Drug dispensation
Singlet state
Sodium chloride
Transmission electron microscopy
Phthalocyanines
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Summary:Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(II), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(L-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12 000 g mol super(-1); polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM sub(68) and PMCM sub(96) with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).
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ISSN:0959-9428
1364-5501
DOI:10.1039/b904224e