Staging disease with Protégé 4: Example of multiple myeloma

Abstract The goal of this study is to add the missing classes and quantitative data properties to the NCI Thesaurus to obtain an applicative ontology that will permit automatic classification. Multiple myeloma is a malignant disorder characterized by the proliferation of a single clone of plasma cel...

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Bibliographic Details
Published inIngénierie et recherche biomédicale Vol. 32; no. 6; pp. 329 - 331
Main Authors Lasbleiz, J, Brillet, E, Decaux, O, Duvauferrier, R, Bertaud-Gounot, V
Format Journal Article
LanguageEnglish
Published Issy-les-Moulineaux Elsevier Masson SAS 01.12.2011
Elsevier Masson
Subjects
Biological and medical sciences
Documentary languages. Terminology
Exact sciences and technology
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Information and communication sciences
Information processing and retrieval
Information science. Documentation
Internal Medicine
Logical and linguistic tools
Medical sciences
Sciences and techniques of general use
Terminology. Lexicons. Thesaurus
Immunopathology
Terminology
Immunoglobulinopathy
Ontology
Thesaurus
Lymphoproliferative syndrome
Classification
Definition
Malignant hemopathy
Myeloma
Cancer
Biomedical engineering
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Summary:Abstract The goal of this study is to add the missing classes and quantitative data properties to the NCI Thesaurus to obtain an applicative ontology that will permit automatic classification. Multiple myeloma is a malignant disorder characterized by the proliferation of a single clone of plasma cells derived from B cells in the bone marrow. We have extracted the multiple myeloma sub-ontology from the NCI Thesaurus. Using Protégé 4, OWL 2.0 and according to last outcomes, new concepts for diagnosis and staging of multiple myeloma have been added to the ontology. A formal description of multiple myeloma variants and stages has been given. The obtained ontology has been checked by a reasoner (FaCT ++) and tested on 20 real medical reports.
ISSN:1959-0318
DOI:10.1016/j.irbm.2011.10.003