Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at kil...

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Published inChemical communications (Cambridge, England) Vol. 48; no. 4; pp. 612 - 614
Main Authors Lai, Chian-Hui, Lin, Yu-Chuan, Chou, Fong-In, Liang, Chien-Fu, Lin, En-Wei, Chuang, Yung-Jen, Lin, Chun-Cheng
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.01.2012
Subjects
Boranes - chemistry
boron
Boron - administration & dosage
Boron - therapeutic use
Boron Neutron Capture Therapy - methods
chemical compounds
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Dendrimers - chemistry
Drug Delivery Systems - methods
Galactose - chemistry
Hep G2 Cells
Humans
irradiation
Neoplasms - radiotherapy
neutrons
Physical Sciences
Science & Technology
therapeutics
DRUG
CHEMISTRY
ASIALOGLYCOPROTEIN
ENDOCYTOSIS
LIPOSOMES
BINDING
CANCER
LIPIDS
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Summary:A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C1CC14447B