Case report: An atypical case of uterine adenosarcoma with extensive bizarre stromal cells and amplification of MDM2

Polypoid lesions in the uterus are very common. There are a lot of benign lesions and malignant tumor should be considered. Adenosarcoma, one of the differential diagnoses, is a rare mixed epithelial and mesenchymal tumor consisting of benign epithelial components and sarcoma stroma. Here, we presen...

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Bibliographic Details
Published inFrontiers in oncology Vol. 14; p. 1351646
Main Authors Xiao, Xiaoling, He, Ying
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.03.2024
Subjects
adenosarcoma
bizarre stromal cells
MDM2
Oncology
polypoid lesions
uterus
adenosarcoma
MDM2
bizarre stromal cells
uterus
polypoid lesions
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Summary:Polypoid lesions in the uterus are very common. There are a lot of benign lesions and malignant tumor should be considered. Adenosarcoma, one of the differential diagnoses, is a rare mixed epithelial and mesenchymal tumor consisting of benign epithelial components and sarcoma stroma. Here, we present a case of atypical adenosarcoma that has never been reported. This tumor was composed of benign endometrial epithelium and hyperplastic stroma with extensive bizarre stromal cells. But the cleft-like spaces and papillary stomal fronds which were the typical histological images of adenosarcoma were absent. These stomal cells, including bizarre cells, were positive for vimentin, CD10, ER, PR, cyclin D1 and P16 but were immunonegative for caldesmon. Furthermore, this tumor harbored amplification of MDM2, as revealed by fluorescence hybridization testing (FISH) and next-generation DNA sequencing (NGS).
Bibliography:Giuseppe Scibilia, Gynecology and Obstetrics Department, Italy
Reviewed by: José Manuel Lopes, University of Porto, Portugal
Edited by: Luigi Tornillo, University of Basel, Switzerland
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1351646