Interferon Alfa–Induced Cardiac Dysfunction

To the Editor: Deyton et al. (Nov. 2 issue) 1 report that reversible left ventricular dysfunction developed in three patients with AIDS while they were being treated with interferon alfa for Kaposi's sarcoma. We agree that the temporal relation between interferon therapy and the development and...

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Published inThe New England journal of medicine Vol. 322; no. 20; p. 1469
Main Authors Cohen, Mylan C, Huberman, Mark S, Nesto, Richard W, Lane, H. Clifford, Deyton, Lawrence R
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 17.05.1990
Subjects
Acquired Immunodeficiency Syndrome - therapy
AIDS/HIV
Cardiomyopathies - etiology
Humans
Interferon Type I - adverse effects
Recombinant Proteins
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Summary:To the Editor: Deyton et al. (Nov. 2 issue) 1 report that reversible left ventricular dysfunction developed in three patients with AIDS while they were being treated with interferon alfa for Kaposi's sarcoma. We agree that the temporal relation between interferon therapy and the development and resolution of left ventricular dysfunction appears to implicate interferon as the factor most likely to explain the cardiac dysfunction in these patients. However, the authors incorrectly describe our report 2 of a patient with renal-cell carcinoma in whom dilated cardiomyopathy developed while she was receiving interferon therapy. She neither had chronic myelogenous leukemia nor died of . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199005173222014