Mid-pregnancy circulating cytokine levels, placental efficiency and their relationship with preterm birth
To assess a panel of cytokines and placental insufficiency with the risk of preterm delivery (PTD). Nested case-control study into the BRISA birth cohort. Eighty-two mother-infant-placenta pairs were selected at 20 to 25 weeks. Circulating biomarker levels were performed using Luminex flowmetric xMA...
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Published in | Revista Brasileira de ginecologia e obstetrícia Vol. 46 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Brazil
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
01.01.2024
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Subjects | |
Online Access | Get full text |
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Summary: | To assess a panel of cytokines and placental insufficiency with the risk of preterm delivery (PTD).
Nested case-control study into the BRISA birth cohort. Eighty-two mother-infant-placenta pairs were selected at 20
to 25
weeks. Circulating biomarker levels were performed using Luminex flowmetric xMAP technology. Cytokines classified as Th1, Th2 or Th17 and other biomarkers were selected. The ratio between birth weight and placental weight (BW/PW) was used as a proxy for placental efficiency. Spearman correlation, univariate analyses and logistic regression models were calculated. Sensitivity, specificity, positive and negative likelihood ratios were calculated using the Receiver Operating Characteristic curve.
Mean gestational age was 250 days, 14,6% were small for gestational age, 4,8% large for gestational age and 13,4% stunted. Placental efficiency was higher for term newborns (p<0,001), and 18/22 (81%) preterm biomarker values were higher than the control group. Th1 cytokines were highly correlated, while the weakest correlation was observed in other biomarkers. Less education was associated with a higher risk of PTD (p = 0.046), while there was no appreciable difference in the risk of PTD for placental insufficiency. Biomarkers showed negligible adjusted OR of PTD (0.90 to 1.02). IL-6, IL-8, IL-1β, TNFβ, IL-4, IL-13, GCSF, MIP1A, VEGF, EGF, and FGF2 presented a higher sensitivity ranging from 75.56% to 91.11%.
IL-8, IL-12p40, IL-4, IL-13, GCSF, MIP1B, and GMSF in asymptomatic pregnant women were associated with PTD. This finding suggests an activation of maternal inflammatory response. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conflicts to interest: none to declare. Associate Editor: Edward Araujo Júnior (https://orcid.org/0000-0002-6145-2532) Universidade Federal de São Paulo, São Paulo, SP, Brazil |
ISSN: | 0100-7203 1806-9339 1806-9339 |
DOI: | 10.61622/rbgo/2024rbgo58 |