Empagliflozin reduces cardiovascular events, mortality and renal events in participants with type 2 diabetes after coronary artery bypass graft surgery: subanalysis of the EMPA-REG OUTCOME® randomised trial

• Published in: Diabetologia Vol. 61; no. 8; pp. 1712 - 1723
• Main Authors: Verma, Subodh, Mazer, C. David, Fitchett, David, Inzucchi, Silvio E., Pfarr, Egon, George, Jyothis T., Zinman, Bernard
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer Nature B.V
• Subjects: Aged; Benzhydryl Compounds - therapeutic use; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Clinical trials; Coronary artery; Coronary Artery Bypass; Coronary vessels; Creatinine; Creatinine - blood; Death; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - therapy; Diabetic Nephropathies - complications; Diabetic Nephropathies - pathology; Double-Blind Method; Drug therapy; Evidence-based medicine; Female; Glomerular Filtration Rate; Glucosides - therapeutic use; Health risk assessment; Heart diseases; Heart failure; Heart Failure - complications; Heart Failure - surgery; Heart surgery; Hospitalization; Human Physiology; Humans; Hypoglycemic Agents - therapeutic use; Internal Medicine; Kidney Diseases - drug therapy; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Mortality; Nephropathy; Proportional Hazards Models; Risk; Sodium; Sodium-glucose cotransporter; Treatment Outcome; Type 2 diabetes; Empagliflozin; Sodium glucose cotransporter 2 inhibition; Diabetes mellitus; Cardiovascular disease; Coronary revascularisation; Coronary artery bypass graft
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-018-4644-9

Aims/hypothesis After coronary artery bypass graft (CABG) surgery in individuals with type 2 diabetes, there remains a considerable residual cardiovascular risk. In the EMPA-REG OUTCOME® trial in participants with type 2 diabetes and established cardiovascular disease, empagliflozin reduced the risk of cardiovascular death by 38%, all-cause mortality by 32%, hospitalisation for heart failure by 35% and incident or worsening nephropathy by 39% vs placebo when given in addition to standard of care. The aim of this post hoc analysis of the EMPA-REG OUTCOME® trial was to determine the effects of the sodium glucose cotransporter 2 inhibitor empagliflozin on cardiovascular events and mortality in participants with type 2 diabetes and a self-reported history of CABG surgery. Methods The EMPA-REG OUTCOME® trial was a randomised, double-blind, placebo-controlled trial. Participants with type 2 diabetes and established cardiovascular disease were randomised 1:1:1 to receive placebo, empagliflozin 10 mg or empagliflozin 25 mg, once daily, in addition to standard of care. In subgroups by self-reported history of CABG (yes/no) at baseline, we assessed: cardiovascular death; all-cause mortality; hospitalisation for heart failure; and incident or worsening nephropathy (progression to macroalbuminuria, doubling of serum creatinine, initiation of renal replacement therapy or death due to renal disease). Differences in risk between empagliflozin and placebo were assessed using a Cox proportional hazards model. Results At baseline, 25% (1175/4687) of participants who received empagliflozin and 24% (563/2333) of participants who received placebo had a history of CABG surgery. In participants with a history of CABG surgery, HRs (95% CI) with empagliflozin vs placebo were 0.52 (0.32, 0.84) for cardiovascular mortality, 0.57 (0.39, 0.83) for all-cause mortality, 0.50 (0.32, 0.77) for hospitalisation for heart failure and 0.65 (0.50, 0.84) for incident or worsening nephropathy. Results were consistent between participants with and without a history of CABG surgery ( p  > 0.05 for treatment by subgroup interactions). Conclusions/interpretation In participants with type 2 diabetes and a self-reported history of CABG surgery, treatment with empagliflozin was associated with profound reductions in cardiovascular and all-cause mortality, hospitalisation for heart failure, and incident or worsening nephropathy. These data have important implications for the secondary prevention of cardiovascular events after CABG in individuals with type 2 diabetes. Trial registration: ClinicalTrials.gov NCT01131676