Interaction of adenovirus with antibodies, complement, and coagulation factors

Adenovirus (AdV) is one of the most widely used vectors for gene therapy and vaccine studies due to its excellent transduction efficiency, capacity for large transgenes, and high levels of gene expression. When administered intravascularly, the fate of AdV vectors is heavily influenced by interactio...

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Bibliographic Details
Published inFEBS letters Vol. 593; no. 24; pp. 3449 - 3460
Main Authors Allen, Rondine J., Byrnes, Andrew P.
Format Journal Article
LanguageEnglish
Published England 01.12.2019
Subjects
adenovirus
complement
gene therapy
immunoglobulin G
immunoglobulin M
natural antibody
tripartite motif‐containing protein 21
vitamin K‐dependent coagulation factors
immunoglobulin G
immunoglobulin M
vitamin K-dependent coagulation factors
adenovirus
gene therapy
complement
natural antibody
tripartite motif-containing protein 21
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Summary:Adenovirus (AdV) is one of the most widely used vectors for gene therapy and vaccine studies due to its excellent transduction efficiency, capacity for large transgenes, and high levels of gene expression. When administered intravascularly, the fate of AdV vectors is heavily influenced by interactions with host plasma proteins. Some plasma proteins can neutralize AdV, but AdV can also specifically bind plasma proteins that protect against neutralization and preserve activity. This review summarizes the plasma proteins that interact with AdV, including antibodies, complement, and vitamin K‐dependent coagulation factors. We will also review the complex interactions of these plasma proteins with each other and with cellular proteins, as well as strategies for developing better AdV vectors that evade or manipulate plasma proteins.
Bibliography:ObjectType-Article-2
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ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13649