Role of Toll-like receptors in inflammatory response in macrophages

The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the infla...

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Bibliographic Details
Published inCritical care medicine Vol. 29; no. 7 Suppl; p. S16
Main Author Aderem, A
Format Journal Article
LanguageEnglish
Published United States 01.07.2001
Subjects
Bacterial Infections - immunology
Drosophila Proteins
Humans
Immunity, Innate - immunology
Inflammation - immunology
Lipopolysaccharides - immunology
Macrophage Activation - immunology
Macrophages - immunology
Membrane Glycoproteins - immunology
Receptors, Cell Surface - immunology
Signal Transduction - immunology
Toll-Like Receptors
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Summary:The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response.
ISSN:0090-3493
1530-0293
DOI:10.1097/00003246-200107001-00008