Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity
This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed th...
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Published in | Magnetic resonance in medicine Vol. 45; no. 6; pp. 1122 - 1125 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.06.2001
Williams & Wilkins |
Subjects | |
Online Access | Get full text |
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Summary: | This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and trabecular thickness were decreased, and apparent trabecular spacing increased, significantly (P < 0.05) in hindlimb‐suspended mice compared to controls. These changes agreed well with light microcopy measurements from an independent study and also with actual spaceflight experiments with rats. Magn Reson Med 45:1122–1125, 2001. © 2001 Wiley‐Liss, Inc. |
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Bibliography: | ark:/67375/WNG-0LTQRWDP-8 NIH - No. SIG 1 S10 RR06293; No. DCCA 92-82144 ArticleID:MRM1148 istex:C3A8DAB7C46A646820E716350AC5E9C7FF4847DB PHS - No. P41 RR05964 NIMH - No. 5F30 MH 11041-05 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0740-3194 1522-2594 |
DOI: | 10.1002/mrm.1148 |