Strain‐level immunomodulatory variation of gut bacteria

The gut microbiota and the immune system have co‐evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human‐derived gut microbes across phyla showed that bacteria‐induced immunomodulations are not dictated by the bacterial ph...

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Bibliographic Details
Published inFEBS letters Vol. 595; no. 9; pp. 1322 - 1327
Main Authors Hajjo, Haitham, Geva‐Zatorsky, Naama
Format Journal Article
LanguageEnglish
Published England 01.05.2021
Subjects
bacterial strains
colon
gut microbiota
immune system
immunomodulatory bacteria
systemic immunity
colon
immune system
immunomodulatory bacteria
systemic immunity
bacterial strains
gut microbiota
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Summary:The gut microbiota and the immune system have co‐evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human‐derived gut microbes across phyla showed that bacteria‐induced immunomodulations are not dictated by the bacterial phylogeny. Yet, it remains unclear whether strains from the same species induce the same immunomodulatory effects on the host. We analyzed the strain‐level data from this recent study and found that strains from the same species can induce distinct and sometimes even opposing immunophenotypes. Hence, we suggest that the immunomodulatory capabilities of gut bacteria can be strain‐specific.
Bibliography:Edited by Renee Tsolis
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ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.14057