Acute promyelocytic leukemia associated with a paraprotein that reacts with leukemic cells

A 29‐year‐old woman developed acute promyelocytic leukemia during pregnancy. At diagnosis, immediately postpartum, she was found to have IgG kappa immunoglobulin on the surface of the leukemic cells as well as a monoclonal protein of IgG kappa specificity in her serum. These resolved with chemothera...

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Bibliographic Details
Published inCancer Vol. 63; no. 9; pp. 1750 - 1751
Main Authors Atkins, Harry, Drouin, Jeanne, Izaguirre, Carlos A., Sengar, Dharmendra S.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.05.1989
Subjects
Adult
Female
Humans
Immunoglobulin G - analysis
Immunoglobulin kappa-Chains - analysis
Leukemia, Promyelocytic, Acute - immunology
Pregnancy
Pregnancy Complications, Neoplastic - immunology
Receptors, Antigen, B-Cell - analysis
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Summary:A 29‐year‐old woman developed acute promyelocytic leukemia during pregnancy. At diagnosis, immediately postpartum, she was found to have IgG kappa immunoglobulin on the surface of the leukemic cells as well as a monoclonal protein of IgG kappa specificity in her serum. These resolved with chemotherapy which induced a complete remission. Immunoglobulin gene rearrangement was not found in the leukemic cells, thus indicating that the blasts were not secreting the monoclonal protein. The authors believe that the patient had an autoantibody directed at myeloid cells which was amplified by the development of the leukemic process.
Bibliography:ObjectType-Case Study-2
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19900501)63:9<1750::AID-CNCR2820630915>3.0.CO;2-G