Utilizing DNA for functionalization of biomaterial surfaces

DNA sequences are widely used for gene transfer into cells including a number of substrate surface‐based supporting systems, but due to its singular structure property profile, DNA also offers multiple options for noncanonical applications. The special case of using DNA and oligodeoxyribonucleotide...

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Bibliographic Details
Published inFEBS letters Vol. 592; no. 12; pp. 2181 - 2196
Main Authors Scharnweber, Dieter, Bierbaum, Susanne, Wolf‐Brandstetter, Cornelia
Format Journal Article
LanguageEnglish
Published England 01.06.2018
Subjects
DNA
implants
surface functionalization
implants
DNA
surface functionalization
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Summary:DNA sequences are widely used for gene transfer into cells including a number of substrate surface‐based supporting systems, but due to its singular structure property profile, DNA also offers multiple options for noncanonical applications. The special case of using DNA and oligodeoxyribonucleotide (ODN) structures for surface functionalization of biomedical implants is summarized here with the major focus on (a) immobilization or anchoring of nucleic acid structures on substrate surfaces, (b) incorporation of biologically active molecules (BAM) into such systems, and (c) biological characteristics of the resulting surfaces in vitro and in vivo. Sterilizations issues, important for potential clinical applications, are also considered.
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ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13065