Morphophysiological alterations in fruit‐eating bats after oral exposure to deltamethrin

• Published in: International journal of experimental pathology Vol. 103; no. 5; pp. 219 - 230
• Main Authors: Oliveira, Jerusa Maria, Condessa, Suellen Silva, Destro, Ana Luiza Fonseca, Lima, Graziela Domingues Almeida, Carmo Cupertino, Marli, Cardoso, Silvia Almeida, Freitas, Mariella Bontempo, Oliveira, Leandro Licursi
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.10.2022; John Wiley and Sons Inc
• Subjects: Animals; Artibeus lituratus; Chiroptera; Crops; Degeneration; Deltamethrin; Eating; Exposure; Fruits; Glycogen; Glycogens; Hepatocytes; Histopathology; Hyperplasia; Inflammation; insecticide pyrethroid; Insecticides; Intestine; Kidneys; Liver; Low concentrations; Mucin; Mucins; Necrosis; Nitric oxide; Original; Proximal tubules; Pyrethroids; Steatosis; toxicology
• ISSN: 0959-9673; 1365-2613; 1365-2613
• DOI: 10.1111/iep.12455

Deltamethrin (DTM) is a synthetic pyrethroid widely used in the cultivation and management of several crops due to its insecticidal action. Application to crops of pyrethroids such as DTM can result in the exposure of water and fruit consumed by fruit bats having a high pyrethroid content which may be harmful. Therefore the objective of this study was to evaluate the effects of short‐term oral exposure of the fruit‐eating bats (Artibeus lituratus) to two concentrations of DTM (0.02 and 0.04 mg/kg of papaya) on histopathology of the intestine, liver and kidney. The intestine of the animals exposed to both concentrations showed inflammatory infiltrate, degeneration, necrosis and goblet cell hyperplasia as the most frequent pathologies. Besides, the acid mucins showed an increase in the frequency of non‐viable cells. The liver showed hepatocyte vacuolizatio and nuclear enlargement, as well as inflammatory infiltrate and steatosis. The kidneys of the exposed animals showed and inflammatory infiltrate, benign nephrosclerosis, vacuolization and necrosis. Also, DTM reduced nitric oxide synthesis, decreased glomerular diameter and increased glycogen percentage in the proximal tubules. Our results suggest that acute exposure to DTM at low concentrations has the potential to induce pronounced histopathological changes in vital organs, such as intestine, liver and kidney of fruit‐eating bats.