Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex

Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlati...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 18; pp. 3207 - 3210
Main Authors Wheelhouse, Richard T, Garbett, Nichola C, Buurma, Niklaas J, Chaires, Jonathan B
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 19.04.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
DNA-RNA hybrids
drug discovery
molecular recognition
pyrimidine
RNaseH
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Summary:Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.
Bibliography:http://dx.doi.org/10.1002/anie.200907235
ArticleID:ANIE200907235
We thank the British Association for Cancer Research for a Mid-career Fellowship (R.T.W.), the NIH (grant number GM077422; J.B.C.), and the EPSRC (grant number EP/D001641/1; N.J.B.).
NIH - No. GM077422
istex:779FCE4ADD4A1A98612E3D2ECD150A4FFAE61CA7
ark:/67375/WNG-CJRF7GLQ-3
EPSRC - No. EP/D001641/1
We thank the British Association for Cancer Research for a Mid‐career Fellowship (R.T.W.), the NIH (grant number GM077422; J.B.C.), and the EPSRC (grant number EP/D001641/1; N.J.B.).
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200907235