Influence of β-Globin Haplotypes on Oxidative Stress, Antioxidant Capacity and Inflammation in Sickle Cell Patients of Chhattisgarh

The present study was conducted to investigate the frequency of β-globin gene haplotype and their influence on oxidative stress, antioxidant level and inflammation of sickle cell patient of Chhattisgarh. The serum levels of total antioxidant capacity, oxidative stress and inflammation were measured...

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Published inIndian journal of clinical biochemistry Vol. 34; no. 2; pp. 201 - 206
Main Authors Bhagat, Sanjana, Thakur, Amar Singh
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.04.2019
Springer Nature B.V
Subjects
Antioxidants
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Haplotypes
Inflammation
Life Sciences
Microbiology
Original
Original Research Article
Oxidative stress
Pathology
Serum levels
Oxidative stress
Inflammation
HbF level
Sickle cell disease
Haplotype
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Summary:The present study was conducted to investigate the frequency of β-globin gene haplotype and their influence on oxidative stress, antioxidant level and inflammation of sickle cell patient of Chhattisgarh. The serum levels of total antioxidant capacity, oxidative stress and inflammation were measured in hundred SCD patients. The mean serum CRP and MDA levels were significantly ( p  < 0.0001) lower in Arab-Indian haplotype when compared with Bantu and other haplotype. However, the antioxidant capacity and HbF levels were significantly higher in Arab-Indian haplotype. These result indicate that β-globin gene haplotype have a role in modulating disease severity in SCD patients of Chhattisgarh.
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ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-017-0729-3