Whey and Buttermilk‐Based Formulas Modulate Gut Microbiota in Mice with Antibiotic‐Induced Dysbiosis
Scope Diet is one of the main factors that modifies intestinal microbiota composition. The search for foods that can reverse situations of intestinal dysbiosis such as that induced by antibiotics is of great interest. Buttermilk and whey are the main by‐products produced by the dairy industry contai...
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Published in | Molecular nutrition & food research Vol. 67; no. 20; pp. e2300248 - n/a |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc
01.10.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Scope
Diet is one of the main factors that modifies intestinal microbiota composition. The search for foods that can reverse situations of intestinal dysbiosis such as that induced by antibiotics is of great interest. Buttermilk and whey are the main by‐products produced by the dairy industry containing bioactive compounds. The aim of this study is to investigate the ability of whey and buttermilk‐based formulas supplemented with lactoferrin and milk fat globule membrane (MFGM) to modulate the effects of clindamycin on mouse intestinal microbiota.
Methods and results
Male C57BL/6 mice are treated with saline (control), clindamycin (Clin), a formula containing whey (F1) or buttermilk (F2), Clin+F1 or Clin+F2, and their fecal microbiota profiles are analyzed by sequencing of 16S rRNA gene using the MinION device. Clin induces alterations in both the composition and metabolic functions of the mice intestinal microbiota. The treatment with F1 or F2 reverses the effects of clindamycin, restoring the levels of Rikenellaceae and Lactobacillaceae families and certain pathways related to short‐chain fatty acids production and tetrahydrofolate biosynthesis.
Conclusion
Whey and buttermilk supplemented with lactoferrin and MFGM may be a bioactive formula for functional foods to prevent or restore microbiota alterations induced by antibiotic administration.
Whey and buttermilk may be good ingredients to add in functional foods to prevent or restore microbiota alterations induced by antibiotic administration. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1613-4125 1613-4133 |
DOI: | 10.1002/mnfr.202300248 |