Evaluation of the Effect of Antibacterial Toothpastes Containing Chlorhexidine and Amine Fluoride on Oral Flora in Patients Undergoing Orthodontic Treatment—A Randomised Controlled Trial

• Published in: International journal of dental hygiene Vol. 23; no. 2; pp. 319 - 329
• Main Authors: Sabuncuoğlu, Fidan Alakuş, Akgün, Özlem Martı, Yıldırım, Ceren, Azizov, Rashad, Özgürtaş, Taner, Demir, Pervin, Kaplan, Ceren, Altun, Ceyhan
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2025
• Subjects: Adolescent; amine fluoride; Amines - pharmacology; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents, Local - pharmacology; Biofilms; Biofilms - drug effects; Chlorhexidine; Chlorhexidine - pharmacology; Dental Plaque - microbiology; Dental Plaque - prevention & control; Dental Plaque Index; Dentifrices; Factorial experiments; Female; Fluoride treatments; Fluorides; Fluorides - pharmacology; Fluorides, Topical; Gingival index; Gingivitis; Humans; Immunoglobulin A; Male; Mouth - microbiology; Orthodontic Appliances, Fixed - microbiology; orthodontic treatment; Orthodontics; Periodontal Index; Plaque index; Toothpaste; Toothpastes - pharmacology; amine fluoride; orthodontic treatment; toothpaste; chlorhexidine
• ISSN: 1601-5029; 1601-5037; 1601-5037
• DOI: 10.1111/idh.12861

ABSTRACT Objectives To compare the efficacy of chlorhexidine (CHX) and amine fluoride (AF) toothpastes on oral flora in fixed orthodontic treatment patients. Methods Thirteen patients were given toothpaste containing AF, and 12 patients were given toothpaste containing CHX. Microbial and periodontal records were taken before, 1 week, and 5 weeks after the bonding procedure. Gingival index (GI), plaque index (PI), and bleeding on probing (BOP) values were recorded by the same expert calibrated before the study. Biofilm samples were taken, and then colony counts of the samples were evaluated. Whether the variable values obtained in the groups at the time of measurement were different was examined by Nonparametric Analysis of Longitudinal Data in Factorial Experiments—Nonparametric Tests for the F1_LD_F1 design for longitudinal data. Results Gender distribution was similar in the study groups (χ2 = 1.944; p = 0.163). The mean age of the patients did not differ in the groups (t = 0.502; p = 0.620). In general, the variable values analysed within the scope of the study did not show significant differences between groups and time (p > 0.05). When the pairwise interactions were analysed, it was found that there was a significant difference only for PI values (F = 3.411; p = 0.035). Conclusions While there were no significant differences observed in BOP, GI, and S. mutans levels and changes in IgA and IgE values between toothpastes containing CHX and AF, the PI index of CHX‐containing toothpastes exhibited a notably lower level. Both AF‐ and CHX‐containing toothpastes can be used for managing biofilm, controlling bacteria, and minimising gingivitis in subjects undergoing fixed orthodontic treatment.