Renal carnitine concentration decreases in endotoxic dogs

Renal cortical and serum carnitine concentrations were studied in seven anesthetized beagle dogs in which acute circulatory collapse was induced by an iv injection of Escherichia coli endotoxin, 0.5 mg/kg given over 15 mins. Four controls received normal saline. The endotoxin injection resulted in c...

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Bibliographic Details
Published inCritical care medicine Vol. 19; no. 6; p. 792
Main Authors Gullichsen, E, Heinonen, O J, Nelimarkka, O, Kuttila, K, Niinikoski, J
Format Journal Article
LanguageEnglish
Published United States 01.06.1991
Subjects
Animals
Carnitine - analysis
Carnitine - blood
Dogs
Endotoxins - blood
Escherichia coli
Female
Hemodynamics - drug effects
Kidney Cortex - chemistry
Male
Renal Circulation
Toxemia - blood
Toxemia - physiopathology
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Summary:Renal cortical and serum carnitine concentrations were studied in seven anesthetized beagle dogs in which acute circulatory collapse was induced by an iv injection of Escherichia coli endotoxin, 0.5 mg/kg given over 15 mins. Four controls received normal saline. The endotoxin injection resulted in cardiac depression, renal hypoperfusion, acidosis with a decrease in urinary output, and hematuria. Arterial and renal venous free carnitine concentrations increased significantly in endotoxemia during the 5-hr experiment, but remained low and unchanged in the controls. Circulating acyl-carnitine concentrations underwent no essential changes in either group. Total, free, and acyl-carnitine concentrations decreased in endotoxic renal tissue. These data suggest that endotoxemia decreases carnitine concentrations in the renal cortex, but increases free carnitine concentrations in the circulation.
ISSN:0090-3493
DOI:10.1097/00003246-199106000-00011