Pathologically catalyzed physical coating restores the intestinal barrier for inflammatory bowel disease therapy

Intestinal epithelia impairment of inflammatory bowel disease (IBD) leads to the leakage of bacteria and antigens and the consequent persistent immune imbalance. Restoring the epithelial barrier is a promising therapeutic target but lacks effective and safe clinical interventions. By identifying the...

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Published inJournal of nanobiotechnology Vol. 21; no. 1; pp. 1 - 444
Main Authors Zhao, Yuge, He, Ruiqing, Zang, Jie, Yin, Weimin, Su, Runping, Xiong, Wei, Xu, Weihua, Zhang, Jiaxin, Liu, Yiqiong, Ren, Tianbin, Huang, Yongzhuo, Li, Yongyong
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 24.11.2023
BioMed Central
BMC
Subjects
Antigens
Care and treatment
Catalase
Catalysis
Coating
Coatings
Colon
Dopamine
Health aspects
Homeostasis
In vivo methods and tests
Inflammatory bowel Disease
Inflammatory bowel diseases
Intestinal barrier
Intestine
Leakage
Materials research
Nanoparticles
Oxidation
Pathological catalysis
Polydopamine coating
Polymerization
Polymers in medicine
Protective coatings
Substrates
Therapeutic targets
Therapy
China
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Summary:Intestinal epithelia impairment of inflammatory bowel disease (IBD) leads to the leakage of bacteria and antigens and the consequent persistent immune imbalance. Restoring the epithelial barrier is a promising therapeutic target but lacks effective and safe clinical interventions. By identifying the catalase (CAT) presence in the IBD pathological environment, we herein develop a CAT-catalyzed pathologically coating on the damaged epithelial barrier to inhibit intestinal leakage for IBD therapy. With the codelivery of CaO.sub.2 (a CAT substrate) and dopamine, the nanosystem can enable CAT-catalyzed oxygen (O.sub.2) production and in-situ polymerization of dopamine and then yield a thin and integrative polydopamine (PDA) coating on the intestinal barrier due to the highly adhesive property of PDA. In vivo study demonstrates that PDA coating provides not only a protective barrier by restricting intestinal leakage but also a favorable anti-inflammation effect. Beyond drug management, this work provides a physical repair strategy via catalyzed coating for IBD therapy.
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-023-02227-0