Risks of second primary breast and urogenital cancer following female breast cancer in the south of The Netherlands, 1972–2001

A cohort of 9919 breast cancer patients from the population-based Eindhoven Cancer Registry was followed for vital status and development of second cancer. Person-year analysis was applied to determine the risk of second primary breast or urogenital cancer among breast cancer patients and to assess...

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Bibliographic Details
Published inEuropean journal of cancer (1990) Vol. 41; no. 15; pp. 2331 - 2337
Main Authors Soerjomataram, I., Louwman, W.J., Lemmens, V.E.P.P., de Vries, E., Klokman, W.J., Coebergh, J.W.W.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.2005
Elsevier
Subjects
Adult
Age Distribution
Age of Onset
Biological and medical sciences
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - therapy
Cohort Studies
Female
Humans
Long term
Medical sciences
Menopause
Middle Aged
Neoplasms, Second Primary - epidemiology
Netherlands - epidemiology
Pharmacology. Drug treatments
Risk Factors
Second primary breast or urogenital cancer
Time Factors
Treatment
Tumors
Urogenital Neoplasms - epidemiology
Urogenital Neoplasms - therapy
Netherlands
Europe
Breast cancer
Treatment
Long term
Second primary breast or urogenital cancer
Pharmacology
Malignant tumor
Epidemiology
Mammary gland diseases
Cancerology
Second cancer
Risk factor
Primary
Female
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Summary:A cohort of 9919 breast cancer patients from the population-based Eindhoven Cancer Registry was followed for vital status and development of second cancer. Person-year analysis was applied to determine the risk of second primary breast or urogenital cancer among breast cancer patients and to assess its correlation with age, treatment and time since the first breast cancer diagnosis. Women with previous breast cancer have an elevated risk of overall second breast or urogenital cancer. The largest relative risk was observed for second breast cancer (SIR (standardised incidence ratio) 3.5; 95% confidence interval (CI) 3.2–3.8) and second ovarian cancer (SIR 1.7; 95% CI 1.2–2.3). The absolute excess risk was highest for second breast cancer (64/10,000 patients/year). However, breast cancer has an inverse relationship to risk of cervical cancer. Changes in behavioural risk factors are important for lowering the risk of second cancer after breast cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2005.01.029