A review on alloy design, biological response, and strengthening of β-titanium alloys as biomaterials

• Published in: Materials Science & Engineering C Vol. 121; p. 111661
• Main Authors: Sidhu, Sarabjeet Singh, Singh, Harpreet, Gepreel, Mohamed Abdel-Hady
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2021; Elsevier BV
• Subjects: Alloy development; Alloying elements; Alloys; Alloys design; Biocompatibility; Biocompatible Materials - pharmacology; Biomaterials; Biomedical materials; Elastic Modulus; Implants; Low cost; Materials science; Materials Testing; Medical research; Physical properties; Prostheses and Implants; Strengthening; Surgical implants; Synchronism; Titanium; Titanium alloys; Titanium base alloys; β- titanium; Strengthening; Biocompatibility; β- titanium; Alloys design; Low cost; Implants
• ISSN: 0928-4931; 1873-0191; 1873-0191
• DOI: 10.1016/j.msec.2020.111661

From the past few years, developments of β-Ti alloys have been the subject of active research in the medical domain. The current paper highlights significant findings in the area of β-Ti alloy design, biological responses, strengthening mechanisms, and developing low-cost implants with a high degree of biocompatibility. It is evident that an astonishing demand for developing the low modulus-high strength implants can be fulfilled by synchronizing β stabilizer content and incorporating tailored thermo-mechanical techniques. Furthermore, the biological response of the implants is as important as the physical properties that regulate healing response; hence, the optimum selection of alloying elements plays a curial role for clinical success. The paper also presents the evolution of patents in this field from the year 2010 to 2020 showing the relevant innovations that may benefit a wide range of researchers. [Display omitted] •Design concepts to develop low modulus β-Ti alloys are reviewed.•Biological performance metrics of various alloying elements and their effective cost have been addressed.•Insight into the thermo-mechanical strengthening strategies to tailor high-strength to low-modulus implants.