Galanin receptor ligands

The three galanin receptor subtypes (GalR1–3) belong to the G protein-coupled receptor superfamily. The widespread distribution of galanin and its receptors in the CNS and PNS and the numerous physiological and pharmacological effects of galanin (for review, cf. Vrontakis, 2002) render the three gal...

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Published inNeuropeptides (Edinburgh) Vol. 39; no. 3; pp. 143 - 146
Main Authors Lu, Xiaoying, Lundström, Linda, Langel, Ulo, Bartfai, Tamas
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Elsevier Ltd 01.06.2005
Elsevier
Subjects
Agonist
Animals
Antagonist
Biological and medical sciences
Drug Design
Fundamental and applied biological sciences. Psychology
Galanin
Galanin receptors
Humans
Ligands
Neuropeptides - metabolism
Receptors, Galanin - agonists
Receptors, Galanin - antagonists & inhibitors
Receptors, Galanin - metabolism
Vertebrates: endocrinology
Galanin receptors
Agonist
Antagonist
Galanin
Galanin receptor
Ligand
Neuropeptide
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Summary:The three galanin receptor subtypes (GalR1–3) belong to the G protein-coupled receptor superfamily. The widespread distribution of galanin and its receptors in the CNS and PNS and the numerous physiological and pharmacological effects of galanin (for review, cf. Vrontakis, 2002) render the three galanin receptors attractive drug targets. The industrial efforts, however, have not yet resulted in a wealth of receptor subtype specific agonists or antagonists with high affinity and selectivity. The present paper summarizes the properties of the galanin ligands used at the end of 2004 in the ca. 2000 publications and complements their pharmacological characterization with new data.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2004.12.012