Retrospective investigation of patients exposed to possible transmission of hepatitis C virus by a capillary blood glucose meter

• Published in: The Journal of hospital infection Vol. 63; no. 1; pp. 65 - 69
• Main Authors: Kadi, Z., Saint-Laurent, P., Cadranel, J.F., Joly, C., Dumouchel, P., Jeanne, S., Thiers, V., Ciurana, O., Astagneau, P.
• Format: Journal Article
• Language: English
• Published: Kent Elsevier Ltd 01.05.2006; Elsevier
• Subjects: Aged; Biological and medical sciences; Blood Glucose Self-Monitoring; Capillary blood glucose meter; Cross Infection - etiology; Cross Infection - virology; Diabetes Mellitus, Type 1 - blood; Diabetes. Impaired glucose tolerance; Diabetic patient; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Equipment Contamination; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; HCV; Hepatitis; Hepatitis C - blood; Hepatitis C - transmission; Hospitalization; Human viral diseases; Humans; Infectious diseases; Medical sciences; Retrospective Studies; Transmission; Viral diseases; Viral hepatitis; Capillary blood glucose meter; Hepatitis; Diabetic patient; HCV; Transmission; Endocrinopathy; Human; Hepatitis A virus; Picornaviridae; Diabetes mellitus; Hepatic disease; Glucose; Hepatovirus; Infection; Virus; Viral hepatitis A; Viral disease; Digestive diseases; Blood capillary; Flaviviridae; Hepatitis C virus; Hepacivirus; Viral hepatitis C
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2005.11.008

A 75-year-old female with no known risk factors for hepatitis C virus (HCV) infection was hospitalized and a diagnosis of HCV seroconversion was established (HCV immunoblot and a positive quantitative viral load). An epidemiological investigation revealed that, during a previous hospitalization resulting in a diagnosis of diabetes, she had shared a Glucotrend ® capillary blood glucose meter (CBGM; Roche Diagnostics, France) with a known HCV-positive diabetic patient. Poor hygiene practices were observed when using this device. Since the Glucotrend CBGM had been purchased, the suspected source patient had been hospitalized eight times and another 19 diabetic patients with known anti-HCV antibodies also regularly attended the same hospital. Consequently, 35 diabetic patients who had been hospitalized at the same time as the suspected source patient and 1305 patients who had used the Glucotrend CBGM were invited to undergo serum anti-hepatitis B virus, anti-HCV and anti-human immunodeficiency virus testing. Among the 35 diabetic patients, none of the 24 subjects tested were positive. Among the 1305 other patients, 995 were tested and 19 (2%) were anti-HCV positive. Although this prevalence is higher than that reported in the general French population, this excess risk cannot be attributed to use of the CBGM. Furthermore, molecular analysis showed that the two HCV strains isolated did not belong to the same phylogenetic cluster. However, as a result of this incident, measures were taken to minimize the transmission of bloodborne viruses in the hospital concerned. Other French hospitals were informed by a national alert message from the French Agency for the Safety of Health Products.