Intensity-modulated radiotherapy in patients with head and neck cancer: a European single-centre experience

• Published in: British journal of radiology Vol. 84; no. 1000; pp. 367 - 374
• Main Authors: Van Gestel, D, Van Den Weyngaert, D, Schrijvers, D, Weyler, J, Vermorken, J B
• Format: Journal Article
• Language: English
• Published: England The British Institute of Radiology 01.04.2011
• Subjects: Acute toxicity; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Chemotherapy; Europe - epidemiology; Female; Fibrosis; Head and neck cancer; Head and Neck Neoplasms - epidemiology; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - radiotherapy; Humans; Male; Middle Aged; Mucosa; Neck; Neoplasm Staging; Patient Selection; Radiation; Radiotherapy; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated - methods; Retrospective Studies; Skin; Surgery; Survival; Survival Analysis; Taste; Time Factors; Waiting Lists; xerostomia; Europe
• ISSN: 0007-1285; 1748-880X
• DOI: 10.1259/bjr/67058055

The purpose of this study was to analyse retrospectively the intensity-modulated radiotherapy (IMRT) results in patients with head and neck cancer (HNC) treated between November 2003 and June 2007. Patients with early and locoregionally advanced HNC were treated with inverse-planned step-and-shoot IMRT. The prescribed dose varied from 66 Gy to 70 Gy in those receiving IMRT as definitive treatment and from 60 Gy to 70 Gy in the post-operative setting. IMRT was given alone, after induction chemotherapy (ICT), with concomitant chemotherapy (CRT) or with both. Acute and late toxicities are reported; locoregional control (LRC), locoregional relapse-free survival (LRRFS) and overall survival (OS) were calculated from the start of radiation. IMRT was used in 78 patients (48 as definitive treatment, 30 post-operatively), of whom 20 also received ICT and 35 CRT. Three patients stopped IMRT early, one for toxicity (mucosa). Acute toxicity scoring revealed 5 cases (6%) of severe skin toxicity and 65 cases (83%) of severe mucosal toxicity. After a median follow-up of 18.7 months, late toxicities included xerostomia (44%), loss of taste (14%) and fibrosis of the neck (9%). 16 patients had died, of whom 10 due to tumour recurrence/progression and 2 due to treatment (but not IMRT related). The LRC, LRRFS and OS at 3 years are 66.1%, 48.5% and 60.3% in the definitive IMRT group and 85.4%, 82.5% and 85.9% in the post-operative setting, respectively. We consider IMRT for locoregional HNC feasible not only as a single modality but also after surgery, after induction chemotherapy and concurrently with chemotherapy.