Drops and fibers - how biomolecular condensates and cytoskeletal filaments influence each other

The cellular cytoskeleton self-organizes by specific monomer-monomer interactions resulting in the polymerization of filaments. While we have long thought about the role of polymerization in cytoskeleton formation, we have only begun to consider the role of condensation in cytoskeletal organization....

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Bibliographic Details
Published inEmerging topics in life sciences Vol. 4; no. 3; p. 247
Main Authors Wiegand, Tina, Hyman, Anthony A
Format Journal Article
LanguageEnglish
Published England 11.12.2020
Subjects
Cytoskeleton
Macromolecular Substances
Microtubules
Polymerization
phase separation
condensates
intracellular organization
cytoskeleton
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Summary:The cellular cytoskeleton self-organizes by specific monomer-monomer interactions resulting in the polymerization of filaments. While we have long thought about the role of polymerization in cytoskeleton formation, we have only begun to consider the role of condensation in cytoskeletal organization. In this review, we highlight how the interplay between polymerization and condensation leads to the formation of the cytoskeleton.
ISSN:2397-8554
DOI:10.1042/ETLS20190174