Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a non-superficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of...

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Bibliographic Details
Published inBiomedical optics express Vol. 5; no. 4; pp. 1203 - 1216
Main Authors Agenant, Michelle, Grimbergen, Matthijs, Draga, Ronald, Marple, Eric, Bosch, Ruud, van Swol, Christiaan
Format Journal Article
LanguageEnglish
Published United States Optical Society of America 01.04.2014
Subjects
Clinical Instrumentation
(170.5660) Raman spectroscopy
(300.6450) Spectroscopy, Raman
(170.3890) Medical optics instrumentation
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Summary:A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a non-superficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid(®) solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.
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ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.5.001203