Endocrine profiles of patients with testicular tumors treated with radiotherapy

Blood samples for hormone analysis were obtained 5 to 20 years post-therapy from 12 men with testicular tumors who were originally treated by unilateral orchiectomy followed by abdominal and/or pelvic irradiation. In nine patients (75%) the levels of FSH and LH, and in one patient (8%) the testoster...

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Published inInternational journal of radiation oncology, biology, physics Vol. 9; no. 11; pp. 1723 - 1726
Main Authors Nader, S., Schultz, P.N., Cundiff, J.H., Hussey, D.H., Samaan, N.A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.1983
Subjects
Adolescent
Adult
Dysgerminoma - blood
Dysgerminoma - radiotherapy
Follow-Up Studies
Hormone analysis
Humans
Luteinizing Hormone - blood
Male
Menotropins - blood
Middle Aged
Radiation protection
Radiation therapy
Teratoma - blood
Teratoma - radiotherapy
Testicular Neoplasms - blood
Testicular Neoplasms - radiotherapy
Testicular tumors
Testosterone - blood
Hormone analysis
Radiation therapy
Testicular tumors
Radiation protection
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Summary:Blood samples for hormone analysis were obtained 5 to 20 years post-therapy from 12 men with testicular tumors who were originally treated by unilateral orchiectomy followed by abdominal and/or pelvic irradiation. In nine patients (75%) the levels of FSH and LH, and in one patient (8%) the testosterone values, were outside the ranges found in age- and sex-matcbed controls. From this retrospective study we conclude that, even when the remaining testis is kept outside the field of radiation, significant radiation damage occurs, mainly through scatter. This damage is more likely to occur if the henniscrotum is irradiated. Methods of shielding are available to reduce the dose received by the contralateral testis.
ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(83)90425-X